A couple of questions that interest me more than just, "Do high doses 'work'," whatever "work" means -
1. Are AAS really making us more responsive to training, such that AAS + proper training has a synergistic effect? Or do we actually have our training stimulus and our gear stimulus, and the two remain separate? Paul Carter and Kurt Havens have been talking about this lately. Tbh I think we all assume(d) the former - that the drugs up-regulate protein synthesis from training...but I wonder if that's not really true. There's the oft-cited study in which men taking 600mg Test and not training gained way more muscle than natties training. It's easy to hand-wave and say that doesn't apply to our population, but to be fair we don't know that it doesn't. We're just unlikely to get a study that tests whether 1.5-2g gear allows already huge bodybuilders to keep gaining muscle when they lay off training.
My hunch is that AAS actually do improve the response to training itself. One data point in favor of that hunch is that when an enhanced bodybuilder improves a weak body part, it's almost always because they changed their training. Then again, even those improvements tend to come far slower than overall, drug-enhanced gains in stage weight. Either way it's an interesting question to consider...and maybe a hard pill to swallow if the truth is otherwise. If we look at how slow gains come to experienced natties, that would mean the drugs are actually accounting for the VAST majority of progress made by experienced enhanced guys.
2. To what degree is AAS dose responsible for body composition? Almost everyone softens up, at least slightly, if they go from blast to cruise / TRT for a couple months. Is that really because the hormones were supporting their combination of muscularity and low body fat on blast, or are people just not accounting for variables (diet, cardio, training intensity) as well as they think they are? The answer might seem obvious if we only look at extremes, e.g. of course you'll be softer eating 5,000 calories on TRT compared to the same intake on 2-3g AAS. But is there really much difference in this regard for a man who drops from 2g to 1g?
You might say dose escalations are necessary to make use of higher food, but anecdotally that hasn't exactly proven true for me...not for AAS, at least. A little bit for GH. But the times I've ramped gear up in hopes of it making me leaner at a given size, it hasn't really panned out that way. And if we consider the numbers at play here, it makes sense that it wouldn't. Justin lays out the math here all the time. If you're loaded to the gills and doing everything perfectly with regards to diet, training, and recovery, you're looking at maybe 20-25g protein synthesis per day. That's less than 100 calories of new protein structures, and the energy required to build them isn't much greater. So if your rate of protein synthesis is already maxed, what is even more gear going to do in terms of using more food to make more muscle? In all likelihood you're just going to gain fat and / or sweat more.