What
@lifter is pretty correct. I’ll add a little more.
Moda is the S isomer and the R isomer of the drug. Think like…….your hands. They are structured the same, but if you put your right hand in the sand, and then put your left hand in the hole, it wouldn’t fit in the indentation.
Armodafinil is pure R isomer. It has a substantial difference in pharmacokinetics. After a morning dose, blood levels are still quite elevated at 12-16 hours.
Because of the wide MOA of this drug on increased serotonin, dopamine, norepinephrine AND it’s effects on the reticular formation (potentiation of orexin, glutamate, and histamine receptors) as well as GABA inhibition…….its almost impossible to take armodafinil multiple times a week and NOT fuck up sleep architecture.
But, it builds tolerance very slowly, much easier on your neuro and cardio system than say ritalin/adderral.
Modafinil is inferior on a mg-mg basis, but the S isomer is cleared in about half the time of the R isomer.
that was too many fun facts. Carry on.