Glass in the liver...
USE A FILTER... we break open Fentanyl ampules on a regular basis at work- we supposed to always use a filter to draw it up.
Even if you give a very "clean" break and don't physically see glass in the ampule, it's there. When examined under the microscope for study, cadaver livers have been found with glass in them. The only deduction was glass ampules.
As far as the bacteria- always wipe with alcohol around the neck for 15 seconds, and then use the wipe to help break it open.