- Joined
- Feb 23, 2010
- Messages
- 258
This might have already been addressed elsewhere, but I couldn’t find it.
I filled syringes before, to be used in a week or so with no issues. So recently, I decided to pre-fill several.
I pre-filled 6 syringes in advance, enough for two shots per week for 3 weeks. Shots every Monday and Thursday.
When I was down to three, I had a problem getting the oil out. It clogged. I didn’t see any obvious problems, so I replaced the needle and it worked fine.
That was 4 days ago. Today I was about to use the next one, so it has been in the syringe 16 days. I noticed a thin whiteish string like floater, about a half inch long in the solution. So I obviously didn’t use that one. I took out the last one and it had the same, but this one was stuck to the inside.
So the suspension settled out or there is some issue with the plastic. Either way, they were both tossed.
This led me to do a search. Turns out - - and I should have known this - - 24 hours is the max recommended time to pre-load a syringe.
According to one article I found, a LOT of whatever is suspended in the oil in the plastic syringe is lost within just a single 24 hour period. Over half to three-quarters is lost.
Lesson learned. If you like filling your syringes several days early, you might want to rethink that.
I filled syringes before, to be used in a week or so with no issues. So recently, I decided to pre-fill several.
I pre-filled 6 syringes in advance, enough for two shots per week for 3 weeks. Shots every Monday and Thursday.
When I was down to three, I had a problem getting the oil out. It clogged. I didn’t see any obvious problems, so I replaced the needle and it worked fine.
That was 4 days ago. Today I was about to use the next one, so it has been in the syringe 16 days. I noticed a thin whiteish string like floater, about a half inch long in the solution. So I obviously didn’t use that one. I took out the last one and it had the same, but this one was stuck to the inside.
So the suspension settled out or there is some issue with the plastic. Either way, they were both tossed.
This led me to do a search. Turns out - - and I should have known this - - 24 hours is the max recommended time to pre-load a syringe.
According to one article I found, a LOT of whatever is suspended in the oil in the plastic syringe is lost within just a single 24 hour period. Over half to three-quarters is lost.
Lesson learned. If you like filling your syringes several days early, you might want to rethink that.
Stability Findings Raise Issue of Syringes as Storage Containers - ASHP
Plastic syringes may be popular as a storage container for liquids, but a well-known manufacturer now says its sterile syringes are not intended to store compounded drug solutions for more than 24 hours.
www.ashp.org